The destruction of brain cells begins in small isolated areas in the brain. The appearance of the diseased cells is referred to as "plaques and tangles".

Each area of the brain controls different functions, so depending on where the disease strikes first, will determine the initial symptoms seen. Most commonly the first area of the brain affected is that which stores our most recent memories (short term memories). This is why short term memory loss is often the first sign experienced by people with Alzheimer's disease.

Over time the disease spreads to affect other functions such as the ability to use and understand language; or to perform familiar tasks such as dressing. At the end stage of the disease it is not uncommon for the afflicted person to no longer be able to recognise close members of the family eg. spouse or children. The person becomes totally dependent on a carer to assist with even the most basic of daily activities such as eating, bathing, and toileting.

As the disease progressively ravages the brain, the world becomes an increasingly confusing and frightening place for the person with Alzheimer's disease. It is no wonder that these people often exhibit anger and aggression. At first they know something is amiss, but know neither what it is or what to do about it.

Every day they lose a little more of what makes us human. Indeed, Alzheimer's disease is a disease characterised by loss. Progressively, the victims of this disease lose their: memories; intellect; ability to communicate; recognition of family and friends; jobs; social position; living skills; independence; and dignity. And the list could go on.