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Two
drugs, which are said to improve or preserve memory,
attention span and thinking ability are available
for use in the management of Alzheimer's disease.
Exelon (Rivastigmine hydrogen tartrate) and Aricept
(donepezil) work to restore a particular chemical
in the brain, acetylcholine (pronounced a-set-tile
koleen). Acetylcholine plays an important role in
many brain functions, but is progressively destroyed
in dementia caused by Alzheimer's disease.
Therefore,
these two drugs are only recommended for use in dementia
due to Alzheimer's. However, the benefit gained from
the use of these two drugs is modest at best, and
they can only be used in the early and middle stages
of Alzheimer's disease.
Aricept
has a few advantages over Exelon: it only has to be
given once a day instead of three to four times a
day, and it does not require periodic blood tests
to monitor for possible adverse effects on the liver.
The main side effects of Aricept are dizziness and
mild to moderate gastrointestinal effects such as
nausea, vomiting and diarrhoea.
The
recent addition to the Pharmaceutical Benefits Scheme
listing of these drugs has removed the high cost experienced
in the past by persons wishing to take these medications.
Neither
drug cures or reverses Alzheimer's disease. The stage
of dementia and progression of the underlying disease
process remain unaffected, with mental deterioration
continuing even during drug use. Both drugs simply
"mask" some of the symptoms for a period of time.
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